Issue 96, 2022

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

Abstract

A crucial reaction in harnessing renewable carbon from lignin is O-demethylation. We demonstrate the selective O-demethylation of syringol and guaiacol using different cytochrome P450 enzymes. These can efficiently use hydrogen peroxide which, when compared to nicotinamide cofactor-dependent monooxygenases and synthetic methods, allows for cheap and clean O-demethylation of lignin-derived aromatics.

Graphical abstract: Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

Supplementary files

Article information

Article type
Communication
Submitted
25 8 2022
Accepted
14 10 2022
First published
08 11 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 13321-13324

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

A. C. Harlington, K. E. Shearwin, S. G. Bell and F. Whelan, Chem. Commun., 2022, 58, 13321 DOI: 10.1039/D2CC04698A

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