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Abstract | Cited by

A novel tactic for the regioselective O-alkylation of 2-pyridones has been realized through palladium catalysis in moderate to high yields. The coordination effect between palladium and nitrogen on the pyridine ring plays a versatile role.

Graphical abstract: Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

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