Issue 7, 2021

Enhanced voltammetric anion sensing at halogen and hydrogen bonding ferrocenyl SAMs

Abstract

Halogen bonding mediated electrochemical anion sensing has very recently been established as a potent platform for the selective and sensitive detection of anions, although the principles that govern binding and subsequent signal transduction remain poorly understood. Herein we address this challenge by providing a comprehensive study of novel redox-active halogen bonding (XB) and hydrogen bonding (HB) ferrocene-isophthalamide-(iodo)triazole receptors in solution and at self-assembled monolayers (SAMs). Under diffusive conditions the sensory performance of the XB sensor was significantly superior. In molecular films the XB and HB binding motifs both display a notably enhanced, but similar, response to specific anions. Importantly, the enhanced response of these films is rationalised by a consideration of the (interfacial) dielectric microenvironment. These effects, and the resolved relationship between anion binding and signal transduction, underpin an improved fundamental understanding of anion sensing at redox-active interfaces which will benefit not just the development of more potent, real-life relevant, sensors but also new tools to study host–guest interactions at interfaces.

Graphical abstract: Enhanced voltammetric anion sensing at halogen and hydrogen bonding ferrocenyl SAMs

Supplementary files

Article information

Article type
Edge Article
Submitted
11 11 2020
Accepted
15 12 2020
First published
15 12 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 2433-2440

Enhanced voltammetric anion sensing at halogen and hydrogen bonding ferrocenyl SAMs

R. Hein, X. Li, P. D. Beer and J. J. Davis, Chem. Sci., 2021, 12, 2433 DOI: 10.1039/D0SC06210C

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