Issue 58, 2021

Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

Abstract

Antibiotic resistance is one of the most important challenges of the 21st century. However, the growing understanding of bacterial pathogenesis and cell-to-cell communication has revealed many potential strategies for the discovery of drugs that can be used for the treatment of bacterial infections. Interfering with bacterial virulence and/or quorum sensing could be a particularly interesting approach, because it is believed to exert less selective pressure on the bacterial resistance than with traditional strategies, geared toward killing bacteria or preventing their growth. Here, we discuss the mechanism of bacterial virulence, presenting promising strategies and recently synthesized heterocyclic compounds to combat future bacterial infections.

Graphical abstract: Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

Article information

Article type
Review Article
Submitted
17 8 2021
Accepted
01 11 2021
First published
19 11 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 36459-36482

Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

R. H. Abd El-Aleam, R. F. George, H. H. Georgey and H. M. Abdel-Rahman, RSC Adv., 2021, 11, 36459 DOI: 10.1039/D1RA06238G

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