Issue 61, 2021

Application of Pauson–Khand reaction in the total synthesis of terpenes

Abstract

The Pauson–Khand reaction (PKR) is a formal [2 + 2 + 1] cycloaddition involving an alkyne, an alkene and carbon monoxide mediated by a hexacarbonyldicobaltalkyne complex to yield cyclopentenones in a single step. This versatile reaction has become a method of choice for the synthesis of cyclopentenone and its derivatives since its discovery in the early seventies. The aim of this review is to point out the applications of PKR in the total synthesis of terpenes.

Graphical abstract: Application of Pauson–Khand reaction in the total synthesis of terpenes

Article information

Article type
Review Article
Submitted
24 7 2021
Accepted
28 10 2021
First published
29 11 2021
This article is Open Access
Creative Commons BY license

RSC Adv., 2021,11, 38325-38373

Application of Pauson–Khand reaction in the total synthesis of terpenes

M. M. Heravi and L. Mohammadi, RSC Adv., 2021, 11, 38325 DOI: 10.1039/D1RA05673E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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