Issue 51, 2021

Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor

Abstract

All sweeteners are recognized by the sweet taste receptor (T1R2–T1R3). The elucidation of the chemoreception mechanism of receptor–ligand interactions is an attractive topic for researchers. Molecular biology and computational biology techniques can reveal the proposed mechanisms for this topic. Other approaches, including chemical biology (bioorganic chemistry), have helped to identify mechanisms on the basis of molecular structure. In this mini-review, we have summarized the recent progress in the synthesis of sweetener derivatives, which includes the use of photoaffinity labeling of diazirine-based derivatives to elucidate the chemoreception of sweeteners.

Graphical abstract: Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor

Article information

Article type
Review Article
Submitted
22 6 2021
Accepted
21 8 2021
First published
01 10 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 32236-32247

Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor

M. Hashimoto, T. Nakagita and T. Misaka, RSC Adv., 2021, 11, 32236 DOI: 10.1039/D1RA04831G

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