Issue 31, 2021

The phytochemistry, pharmacology and traditional medicinal use of Glechomae Herba – a systematic review

Abstract

Glechomae Herba is a Chinese herb, which has been used in China for thousands of years, mainly for the treatment of nephrolithiasis. This paper summarizes the modern research progress on Glechomae Herba from the aspects of botany, traditional medicinal use, phytochemistry, pharmacology, pharmacokinetics, analytical methods and quality control. In addition, it also points out the deficiencies of current research on this herb and provides possible directions for its development. So far, more than 190 chemical components have been isolated and identified from Glechomae Herba, including organic acids and their esters, volatile oils, flavonoids and their glycosides, terpenes and other chemical components. Its extracts and compounds have a wide range of pharmacological effects, including anti-stone, anti-inflammatory, bacteriostatic, cholagogic and diuretic, effect on ileum smooth muscle, anti-tumor effect on tumor and hypoglycemic effects. However, future studies should focus on drug metabolism, clarify its pharmacodynamic mechanism, and establish a reasonable quality control standards for Glechomae Herba.

Graphical abstract: The phytochemistry, pharmacology and traditional medicinal use of Glechomae Herba – a systematic review

Supplementary files

Article information

Article type
Review Article
Submitted
19 2 2021
Accepted
19 4 2021
First published
27 5 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 19221-19237

The phytochemistry, pharmacology and traditional medicinal use of Glechomae Herba – a systematic review

L. Yang, J. Zhang, S. Zheng, A. Hou, S. Wang, H. Yu, X. Wang, Y. Xu, H. Kuang and H. Jiang, RSC Adv., 2021, 11, 19221 DOI: 10.1039/D1RA01366A

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