Issue 9, 2021

Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products

Abstract

The furo-pyranone framework is widely present in the molecular structure of various biologically potent natural products and un-natural small molecules, and it represents a valuable target in synthetic organic chemistry and medicinal chemistry. In the last five decades, numerous innovative synthetic methodologies have been disclosed for these bis-oxacyclic fused heterocycles, expanding the scope of accessible building blocks, efficient and affordable catalysis, facile reaction conditions, and overall practicality of the process. In this comprehensive review article, we focus on showcasing the complete spectrum (from the first report in the 1970s to the latest disclosure in 2020) of efforts devoted towards the synthesis of diverse classes of furo-pyranones through systematization and critical analysis of the accumulated experimental knowledge and their elegant applications in total syntheses of biologically interesting related natural products.

Graphical abstract: Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products

Article information

Article type
Review Article
Submitted
18 11 2020
Accepted
23 1 2021
First published
25 1 2021

Org. Chem. Front., 2021,8, 2110-2162

Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products

S. S. Thorat and R. Kontham, Org. Chem. Front., 2021, 8, 2110 DOI: 10.1039/D0QO01421D

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