Issue 32, 2021

Highly efficient photothermal nanoparticles for the rapid eradication of bacterial biofilms

Abstract

Biofilm-related infections, such as dental plaque, chronic sinusitis, native valve endocarditis, and chronic airway infections in cystic fibrosis have brought serious suffering to patients and financial burden to society. Materials that can eliminate mature biofilms without developing drug resistance are promising tools to treat biofilm-related infections, and thus they are in urgent demand. Herein, we designed and readily prepared organic nanoparticles (NPs) with highly efficient photothermal conversion by harvesting energy via excited-state intramolecular motions and enlarging molar absorptivity. The photothermal NPs can sufficiently eliminate mature bacterial biofilms upon low-power near-infrared laser irradiation. NPs hold great promise for the rapid eradication of bacterial biofilms by photothermal therapy.

Graphical abstract: Highly efficient photothermal nanoparticles for the rapid eradication of bacterial biofilms

Supplementary files

Article information

Article type
Communication
Submitted
31 5 2021
Accepted
17 7 2021
First published
22 7 2021

Nanoscale, 2021,13, 13610-13616

Highly efficient photothermal nanoparticles for the rapid eradication of bacterial biofilms

W. He, Z. Wang, H. Bai, Z. Zhao, R. T. K. Kwok, J. W. Y. Lam and B. Z. Tang, Nanoscale, 2021, 13, 13610 DOI: 10.1039/D1NR03471E

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