Issue 94, 2021

Structurally screening calixarenes as peptide transport activators

Abstract

Calixarenes are reportedly excellent activators that can remarkably improve the transport efficiencies of cell penetrating peptides. We employed eight calixarenes to systematically study the influence of structure on activation efficiency, which revealed that the scaffold, head group, and alkyl chain are all significant factors for activation efficiency by affecting affinities with the peptide and membrane.

Graphical abstract: Structurally screening calixarenes as peptide transport activators

Supplementary files

Article information

Article type
Communication
Submitted
25 9 2021
Accepted
07 11 2021
First published
08 11 2021

Chem. Commun., 2021,57, 12627-12630

Structurally screening calixarenes as peptide transport activators

D. Zhang, Z. Zheng, H. Zhao, H. Wang, F. Ding, H. Li, Y. Pan and D. Guo, Chem. Commun., 2021, 57, 12627 DOI: 10.1039/D1CC05414G

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