Issue 90, 2021

Transition metal catalyzed C–H bond activation by exo-metallacycle intermediates

Abstract

exo-Metallacycles have become the key reaction intermediates in activating various remote C(sp2)–H and C(sp3)–H bonds in the past decade and aided in achieving unusual site-selectivity. Various novel exo-chelating auxiliaries have assisted metals to reach desired remote C–H bonds of different alcohol and amine-derived substrates. As a result, a wide range of organic transformations of C–H bonds like halogenation, acetoxylation, amidation, sulfonylation, olefination, acylation, arylation, etc. were accessible using the exo-metallacycle strategy. In this review, we have summarized the developments in C–H bond activation via four-, five-, six-, seven- and eight-membered exo-metallacycles and the key reaction intermediates, including the mechanistic aspects, are discussed concisely.

Graphical abstract: Transition metal catalyzed C–H bond activation by exo-metallacycle intermediates

Article information

Article type
Feature Article
Submitted
07 9 2021
Accepted
29 9 2021
First published
29 9 2021

Chem. Commun., 2021,57, 11885-11903

Transition metal catalyzed C–H bond activation by exo-metallacycle intermediates

S. R. Sahoo, S. Dutta, S. A. Al-Thabaiti, M. Mokhtar and D. Maiti, Chem. Commun., 2021, 57, 11885 DOI: 10.1039/D1CC05042G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements