Issue 13, 2020

Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems

Abstract

The establishment of bioorthogonal chemistry is one of the most significant advances in chemical biology using exogenous chemistry to perturb and study biological processes. Photo-modulation of biological systems has realized temporal and spatial control on biomacromolecules in living systems. The combination of photo-modulation and bioorthogonal chemistry is therefore emerging as a new direction to develop new chemical biological tools with spatiotemporal resolution. This minireview will focus on recent development of bioorthogonal chemistry subject to spatiotemporal control through photo-irradiation. Different strategies to realize photo-control on bioorthogonal bond-forming reactions and biological applications of photo-controllable bioorthogonal reactions will be summarized to give a perspective on how the innovations on photo-chemistry can contribute to the development of optochemical biology. Future trends to develop more optochemical tools based on novel photochemistry will also be discussed to envision the development of chemistry-oriented optochemical biology.

Graphical abstract: Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems

Article information

Article type
Minireview
Submitted
27 12 2019
Accepted
07 3 2020
First published
10 3 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 3390-3396

Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems

J. Li, H. Kong, C. Zhu and Y. Zhang, Chem. Sci., 2020, 11, 3390 DOI: 10.1039/C9SC06540G

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