Issue 17, 2020

Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes

Abstract

Nickel-catalyzed three-component alkene difunctionalization has rapidly emerged as a powerful tool for forging two C–C bonds in a single reaction. Building upon the powerful modes of bond construction in traditional two-component cross-coupling, various research groups have demonstrated the versatility of nickel in enabling catalytic 1,2-dicarbofunctionalization using a wide range of carbon-based electrophiles and nucleophiles and in a fully intermolecular fashion. Though this area has emerged only recently, the last few years have witnessed a proliferation of publications on this topic, underscoring the potential of this strategy to develop into a general platform that offers high regio- and stereoselectivity. This minireview highlights the recent progress in the area of intermolecular 1,2-dicarbofunctionalization of alkenes via nickel catalysis and discusses lingering challenges within this reactivity paradigm.

Graphical abstract: Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes

Article information

Article type
Minireview
Submitted
27 11 2019
Accepted
04 3 2020
First published
06 3 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 4287-4296

Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes

J. Derosa, O. Apolinar, T. Kang, V. T. Tran and K. M. Engle, Chem. Sci., 2020, 11, 4287 DOI: 10.1039/C9SC06006E

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