Issue 4, 2020

Asymmetric catalysis in direct nitromethane-free Henry reactions

Abstract

A great number of reports have described asymmetric catalytic Henry reactions using nitromethanes as pronucleophiles, but far more challenging is diastereoselective catalytic Henry reactions using substituted higher nitroalkanes instead of nitromethane to generate chiral β-nitro alcohol scaffolds with four adjacent stereogenic centers in a one-pot operation. This review summarizes the current state and applications of such reactions involving complex nitroalkane coupling with various carbonyl compounds for resolving double chiral centers with high enantio- and diastereoselectivities.

Graphical abstract: Asymmetric catalysis in direct nitromethane-free Henry reactions

Article information

Article type
Review Article
Submitted
07 12 2019
Accepted
06 1 2020
First published
13 1 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 2313-2326

Asymmetric catalysis in direct nitromethane-free Henry reactions

L. Dong and F. Chen, RSC Adv., 2020, 10, 2313 DOI: 10.1039/C9RA10263A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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