Issue 9, 2020

Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Abstract

Magnetic nanoparticle (MNP) integrated biomimetic scaffolds are receiving a lot of attention for the repair of bone defects and in bone tissue engineering applications. In the present work, Fe3O4 MNP integrated polymer/phosphate glass (CG/PG/MNP) composite scaffolds developed using a freeze drying technique are reported. MNP integrated CG/PG composite scaffolds were highly porous in nature with pores of size ranging between 20 and 150 μm and the pores were typically interconnected. Integration of Fe3O4 with CG/PG significantly influenced the swelling and degradation behavior constructively. The CG/PG/MNP composite scaffold exhibited a soft ferromagnetic nature and the compressive modulus increased significantly with increasing MNP content. In addition, the MNP containing CG/PG composite scaffolds demonstrated good bioactivity and cytocompatibility. Based on the results, MNP integrated CG/PG composite scaffolds developed in the present study may be potential scaffolds for bone tissue engineering applications.

Graphical abstract: Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

Associated articles

Article information

Article type
Paper
Submitted
20 7 2020
Accepted
12 10 2020
First published
13 10 2020
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2020,1, 3466-3475

Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

R. Govindan, S. Karthi, G. S. Kumar and E. K. Girija, Mater. Adv., 2020, 1, 3466 DOI: 10.1039/D0MA00525H

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