Issue 30, 2019

Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry

Abstract

This review describes the recent advances in the design of novel artificial metalloenzymes and their application in C–H activation reactions. The combination of enzymes and metal or organometallic complexes for the creation of new artificial metalloenzymes has represented a very exciting research line. In particular, the development of proteins with the ability to perform C–H functionalization presents a significant challenge. Here we discuss the development of these processes on natural metalloenzymes by using directed evolution, biotin-(strept)avidin technologies, photocatalytic hybrids or reconstitution of heme-protein technology.

Graphical abstract: Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry

Article information

Article type
Review Article
Submitted
10 5 2019
Accepted
03 7 2019
First published
04 7 2019
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2019,17, 7114-7123

Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry

C. Perez-Rizquez, A. Rodriguez-Otero and J. M. Palomo, Org. Biomol. Chem., 2019, 17, 7114 DOI: 10.1039/C9OB01091B

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