Issue 7, 2019

Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

Abstract

An unprecedented method for the direct arylation and heteroarylation of tetrahydroisoquinolines under metal and oxidant free conditions is reported. The arylation reactions occurred via a C(sp3)–H functionalization enabled three component condensation of tetrahydroisoquinolines, 9-fluorenone imine, and arenes without involving a pre-functionalization/pre-derivatization step. A wide range of arenes and heteroarenes participated in the reaction to provide structurally diverse arylated tetrahydroisoquinolines with good to excellent yields.

Graphical abstract: Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

Supplementary files

Article information

Article type
Communication
Submitted
18 9 2018
Accepted
24 11 2018
First published
26 11 2018

Org. Biomol. Chem., 2019,17, 1800-1804

Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

S. Haldar and C. K. Jana, Org. Biomol. Chem., 2019, 17, 1800 DOI: 10.1039/C8OB02309C

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