Issue 45, 2018

Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

Abstract

Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc–Pt–HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc–Pt–HA conjugate showed specific uptake, photo-enhanced cytotoxicity (∼1500 fold) and mitochondrial accumulation in breast cancer over normal cells.

Graphical abstract: Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

Supplementary files

Article information

Article type
Communication
Submitted
26 9 2018
Accepted
15 10 2018
First published
24 10 2018

J. Mater. Chem. B, 2018,6, 7373-7377

Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

K. Mitra, M. Samsó, C. E. Lyons and M. C. T. Hartman, J. Mater. Chem. B, 2018, 6, 7373 DOI: 10.1039/C8TB02533A

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