Issue 55, 2018

Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

Abstract

In this study, a novel supramolecular hydrogel system, abbreviated as AGC16/NTS, prepared by molecular self-assembly of cationic gemini surfactant 1,3-bis(N,N-dimethyl-N-cetylammonium)-2-propylacrylatedibromide (AGC16) and anionic aromatic compound trisodium 1,3,6-naphthalenetrisulfonate (NTS), was used to encapsulate hydrophobic model drug curcumin (Cur), constructing a pH-responsive drug delivery system. Cur was effectively encapsulated into the hydrophobic domains of AGC16/NTS through hydrophobic interaction, which was confirmed by 1H NMR measurement. The effects of Cur on the mechanical strength, phase transition behaviour and morphology of AGC16/NTS were characterized by rheology and cryogenic scanning electron microscopy (cryo-SEM) methods. The pH-responsive release of Cur from AGC16/NTS was obtained and the release amount of Cur ascended with pH value decreasing from 7.4 to 3.0. The hydrodynamic sizes of the released Cur-aggregates determined by dynamic light scattering (DLS) were used to analyse the release process of Cur at different pH. The cell viability assay and cell imaging experiment demonstrated that Cur-loaded hydrogel has much higher cytotoxicity and better cell uptake compared to free Cur. Overall, the AGC16/NTS hydrogel is a prospective material for use in encapsulation and controlled-release of hydrophobic drug molecules.

Graphical abstract: Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

Article information

Article type
Paper
Submitted
17 7 2018
Accepted
18 8 2018
First published
10 9 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 31581-31587

Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

L. Wang, X. Shi, J. Zhang, Y. Zhu and J. Wang, RSC Adv., 2018, 8, 31581 DOI: 10.1039/C8RA06064A

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