Issue 14, 2018

A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

Abstract

Functional active wound dressings are expected to provide a moist wound environment, offer protection from secondary infections, remove wound exudate and accelerate tissue regeneration, as well as to improve the efficiency of wound healing. Chitosan-based hydrogels are considered as ideal materials for enhancing wound healing owing to their biodegradable, biocompatible, non-toxic, antimicrobial, biologically adhesive, biological activity and hemostatic effects. Chitosan-based hydrogels have been demonstrated to promote wound healing at different wound healing stages, and also can alleviate the factors against wound healing (such as excessive inflammatory and chronic wound infection). The unique biological properties of a chitosan-based hydrogel enable it to serve as both a wound dressing and as a drug delivery system (DDS) to deliver antibacterial agents, growth factors, stem cells and so on, which could further accelerate wound healing. For various kinds of wounds, chitosan-based hydrogels are able to promote the effectiveness of wound healing by modifying or combining with other polymers, and carrying different types of active substances. In this review, we will take a close look at the application of chitosan-based hydrogels in wound dressings and DDS to enhance wound healing.

Graphical abstract: A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

Article information

Article type
Review Article
Submitted
20 12 2017
Accepted
12 2 2018
First published
16 2 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 7533-7549

A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

H. Liu, C. Wang, C. Li, Y. Qin, Z. Wang, F. Yang, Z. Li and J. Wang, RSC Adv., 2018, 8, 7533 DOI: 10.1039/C7RA13510F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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