Issue 81, 2017

Transformable protein–gold hybrid materials serve as supramolecular vehicles for gene delivery

Abstract

Functional DNA cannot pass through plasma membrane of living cells by itself. An efficient non-viral DNA carrier with low cytotoxicity and simple preparation procedure is in high demand. Herein, we describe that protein–gold hybrid nanocubes (PGHNs) could intrinsically recognize DNAs, and transform them into nanoflower-like structures. These supramolecular complexes can be internalized by living yeast cells and allow the coding information of the gene to be transmitted into proteins. PGHN–DNA can be a good model to study DNA–carrier interactions as well as a new carrier for gene delivery research.

Graphical abstract: Transformable protein–gold hybrid materials serve as supramolecular vehicles for gene delivery

Supplementary files

Article information

Article type
Paper
Submitted
12 9 2017
Accepted
19 10 2017
First published
03 11 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 51252-51256

Transformable protein–gold hybrid materials serve as supramolecular vehicles for gene delivery

Z. Li, H. Ding, F. Yan, H. Li and Z. Chen, RSC Adv., 2017, 7, 51252 DOI: 10.1039/C7RA10141D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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