Issue 61, 2017

Dual modal imaging agents based on chromophore-bearing DTPA analogues

Abstract

Two new DTPA analogues, centrally (L1) and terminally (L2) functionalised with a 1,8-naphthalimide chromophore, have been successfully prepared and fully characterized. Their Gd(III) complexes have also been prepared and evaluated for their ability to act as dual modal contrast agents (MRI/OI). The highly reproducible R1 relaxivity of L1 (8.10 ± 0.21 mM−1 s−1, 25 °C and 30 MHz) is markedly higher than other DTPA based contrast agents. The Gd(III) complexes of both L1 and L2 have been evaluated as luminescence probes; the ligand based fluorescence is not quenched upon complexation.

Graphical abstract: Dual modal imaging agents based on chromophore-bearing DTPA analogues

Supplementary files

Article information

Article type
Paper
Submitted
21 6 2017
Accepted
28 7 2017
First published
04 8 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 38463-38470

Dual modal imaging agents based on chromophore-bearing DTPA analogues

C. Sathiyajith, A. J. Hallett, A. J. Amoroso and P. G. Edwards, RSC Adv., 2017, 7, 38463 DOI: 10.1039/C7RA06946D

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