Issue 69, 2017

Transition metal-catalyzed [2 + 2 + 2] cycloaddition of nitrogen-linked 1,6-diynes: a straightforward route to fused pyrrolidine systems

Abstract

Transition metal-catalyzed [2 + 2 + 2] cycloadditions of nitrogen-linked 1,6-diynes with unsaturated motifs, such as alkynes, alkenes, nitriles, ketenes and isocyanates, have recently attracted more attention from synthetic organic chemists because of their high efficiency in the construction of numerous pyrrolidine based systems. Utilizing different chiral transition metal catalysts to access challenging chiral skeletons has been extensively explored in recent years. We hope to highlight the power of [2 + 2 + 2] cycloaddition chemistry to access a variety of fused pyrrolidine structures from inexpensive and easily available nitrogen-linked 1,6-diynes. The literature has been surveyed until the end of 2016.

Graphical abstract: Transition metal-catalyzed [2 + 2 + 2] cycloaddition of nitrogen-linked 1,6-diynes: a straightforward route to fused pyrrolidine systems

Article information

Article type
Review Article
Submitted
12 5 2017
Accepted
02 8 2017
First published
11 9 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 43716-43736

Transition metal-catalyzed [2 + 2 + 2] cycloaddition of nitrogen-linked 1,6-diynes: a straightforward route to fused pyrrolidine systems

M. Babazadeh, S. Soleimani-Amiri, E. Vessally, A. Hosseinian and L. Edjlali, RSC Adv., 2017, 7, 43716 DOI: 10.1039/C7RA05398C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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