Issue 26, 2017

Recent developments in the synthesis and biological activity of acridine/acridone analogues

Abstract

Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases. Therefore, many scientists seek new, more effective, more selective and less toxic drugs. Acridine/acridone derivatives constitute a class of compounds with a broad spectrum of biological activity and are of great interest to scientists. To date, many acridine/acridone analogues have been obtained, which, inter alia, exhibit antitumour (e.g., (1–5)), antimicrobial (e.g., (59)), and antiviral (e.g., (61)) activities and are applicable in the treatment of Alzheimer's disease (e.g., (26)). However, in many cases, their clinical application is limited and excluded because of side effects. In this survey, we describe acridine and acridone derivatives reported since 2013, methods of their synthesis and their potential clinical applications.

Graphical abstract: Recent developments in the synthesis and biological activity of acridine/acridone analogues

Article information

Article type
Review Article
Submitted
23 1 2017
Accepted
04 3 2017
First published
09 3 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 15776-15804

Recent developments in the synthesis and biological activity of acridine/acridone analogues

M. Gensicka-Kowalewska, G. Cholewiński and K. Dzierzbicka, RSC Adv., 2017, 7, 15776 DOI: 10.1039/C7RA01026E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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