Issue 6, 2017

(1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

Abstract

A family of easily scalable, shelf-stable, optically pure reagents (1S)-(−)-N-trifluoromethylthio-2,10-camphorsultam 1a–c was successfully developed. In particular, compound 1c was shown to be an efficient reagent that is capable of transferring chirality to other prochiral nucleophiles such as β-ketoesters, oxindoles and benzofuranones with good to excellent enantioselectivities.

Graphical abstract: (1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

Supplementary files

Article information

Article type
Research Article
Submitted
16 1 2017
Accepted
09 2 2017
First published
10 2 2017
This article is Open Access
Creative Commons BY-NC license

Org. Chem. Front., 2017,4, 1051-1057

(1S)-(−)-N-Trifluoromethylthio-2,10-camphorsultam and its derivatives: easily available, optically pure reagents for asymmetric trifluoromethylthiolation

H. Zhang, X. Leng, X. Wan and Q. Shen, Org. Chem. Front., 2017, 4, 1051 DOI: 10.1039/C7QO00042A

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