Issue 11, 2017

Benzisoxazole: a privileged scaffold for medicinal chemistry

Abstract

The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials. The number of reports describing benzisoxazole-containing highly active compounds leads to the expectation that this scaffold will further emerge as a potential candidate in the field of drug discovery.

Graphical abstract: Benzisoxazole: a privileged scaffold for medicinal chemistry

Article information

Article type
Review Article
Submitted
01 9 2017
Accepted
05 10 2017
First published
31 10 2017

Med. Chem. Commun., 2017,8, 2023-2039

Benzisoxazole: a privileged scaffold for medicinal chemistry

K. P. Rakesh, C. S. Shantharam, M. B. Sridhara, H. M. Manukumar and H. Qin, Med. Chem. Commun., 2017, 8, 2023 DOI: 10.1039/C7MD00449D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements