Issue 5, 2017

Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Abstract

The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.

Graphical abstract: Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

Supplementary files

Article information

Article type
Communication
Submitted
03 1 2017
Accepted
31 1 2017
First published
31 1 2017
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2017,19, 1226-1229

Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades

S. Schmidt, T. Pedroso de Almeida, D. Rother and F. Hollmann, Green Chem., 2017, 19, 1226 DOI: 10.1039/C7GC00020K

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