Volume 196, 2017

Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

Abstract

Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved. In addition, BSPOTPE, a reported excellent AIE bioprobe for human serum albumin (HSA) quantitation, is used together with IDATPE in artificial urine for UACR testing. The mutual interference of HSA and creatinine when the bioprobes are used for quantitation is characterised, with promising results. Further improvements and potential applications in CKD quantitation are highlighted.

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
24 6 2016
Accepted
05 9 2016
First published
05 9 2016
This article is Open Access
Creative Commons BY license

Faraday Discuss., 2017,196, 351-362

Quantitative urinalysis using aggregation-induced emission bioprobes for monitoring chronic kidney disease

T. Chen, N. Xie, L. Viglianti, Y. Zhou, H. Tan, B. Z. Tang and Y. Tang, Faraday Discuss., 2017, 196, 351 DOI: 10.1039/C6FD00153J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements