Issue 32, 2017

Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

Abstract

By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H)˙, formed in the reaction of guanosine-5′-monophosphate with a triplet-excited 3,3′,4,4′-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G˙+)′.

Graphical abstract: Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

Supplementary files

Article information

Article type
Communication
Submitted
06 6 2017
Accepted
20 7 2017
First published
20 7 2017
This article is Open Access
Creative Commons BY license

Phys. Chem. Chem. Phys., 2017,19, 21262-21266

Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

O. B. Morozova, N. N. Fishman and A. V. Yurkovskaya, Phys. Chem. Chem. Phys., 2017, 19, 21262 DOI: 10.1039/C7CP03797J

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