Issue 9, 2016

Bacterial Cu+-ATPases: models for molecular structure–function studies

Abstract

The early discovery of the human Cu+-ATPases and their link to Menkes and Wilson's diseases brought attention to the unique role of these transporters in copper homeostasis. The characterization of bacterial Cu+-ATPases has significantly furthered our understanding of the structure, selectivity and transport mechanism of these enzymes, as well as their interplay with other elements of Cu+ distribution networks. This review focuses on the structural–functional insights that have emerged from studies of bacterial Cu+-ATPases at the molecular level and how these observations have contributed to drawing up a comprehensive picture of cellular copper homeostasis.

Graphical abstract: Bacterial Cu+-ATPases: models for molecular structure–function studies

Article information

Article type
Critical Review
Submitted
01 4 2016
Accepted
22 7 2016
First published
22 7 2016

Metallomics, 2016,8, 906-914

Author version available

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