Issue 81, 2016

Stabilisation of metastable polymorphs: the case of paracetamol form III

Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

Graphical abstract: Stabilisation of metastable polymorphs: the case of paracetamol form III

Supplementary files

Article information

Article type
Communication
Submitted
15 6 2016
Accepted
05 8 2016
First published
05 8 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 12028-12031

Stabilisation of metastable polymorphs: the case of paracetamol form III

R. Telford, C. C. Seaton, A. Clout, A. Buanz, S. Gaisford, G. R. Williams, T. J. Prior, C. H. Okoye, T. Munshi and I. J. Scowen, Chem. Commun., 2016, 52, 12028 DOI: 10.1039/C6CC05006A

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