Issue 2, 2015

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

Abstract

We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate ‘triangular’ cascade. Employment of up to two C–C bond forming steps allows for the rapid generation of molecular complexity under mild conditions.

Graphical abstract: One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

Supplementary files

Article information

Article type
Communication
Submitted
25 11 2014
Accepted
12 12 2014
First published
18 12 2014
This article is Open Access
Creative Commons BY license

Green Chem., 2015,17, 852-855

Author version available

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

B. R. Lichman, E. D. Lamming, T. Pesnot, J. M. Smith, H. C. Hailes and J. M. Ward, Green Chem., 2015, 17, 852 DOI: 10.1039/C4GC02325K

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