Issue 46, 2014

Nanogel carrier design for targeted drug delivery

Abstract

Polymer-based nanogel formulations offer features attractive for drug delivery, including ease of synthesis, controllable swelling and viscoelasticity as well as drug loading and release characteristics, passive and active targeting, and the ability to formulate nanogel carriers that can respond to biological stimuli. These unique features and low toxicity make the nanogels a favorable option for vascular drug targeting. In this review, we have addressed key chemical and biological aspects of nanogel drug carrier design. In particular, we have highlighted published studies of nanogel design, descriptions of nanogel functional characteristics and their behavior in biological models. These studies form a compendium of information that supports the scientific and clinical rationale for development of this carrier for targeted therapeutic interventions.

Graphical abstract: Nanogel carrier design for targeted drug delivery

Article information

Article type
Feature Article
Submitted
14 7 2014
Accepted
04 9 2014
First published
08 9 2014

J. Mater. Chem. B, 2014,2, 8085-8097

Author version available

Nanogel carrier design for targeted drug delivery

D. M. Eckmann, R. J. Composto, A. Tsourkas and V. R. Muzykantov, J. Mater. Chem. B, 2014, 2, 8085 DOI: 10.1039/C4TB01141D

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