Issue 46, 2014

Biomaterials at the interface of nano- and micro-scale vector–cellular interactions in genetic vaccine design

Abstract

The development of safe and effective vaccines for the prevention of elusive infectious diseases remains a public health priority. Immunization, characterized by adaptive immune responses to specific antigens, can be raised by an array of delivery vectors. However, current commercial vaccination strategies are predicated on the retooling of archaic technology. This review will discuss current and emerging strategies designed to elicit immune responses in the context of genetic vaccination. Selected strategies at the biomaterial–biological interface will be emphasized to illustrate the potential of coupling both fields towards a common goal.

Graphical abstract: Biomaterials at the interface of nano- and micro-scale vector–cellular interactions in genetic vaccine design

Article information

Article type
Feature Article
Submitted
30 6 2014
Accepted
12 9 2014
First published
12 9 2014

J. Mater. Chem. B, 2014,2, 8053-8068

Biomaterials at the interface of nano- and micro-scale vector–cellular interactions in genetic vaccine design

C. H. Jones, A. P. Hakansson and B. A. Pfeifer, J. Mater. Chem. B, 2014, 2, 8053 DOI: 10.1039/C4TB01058B

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