Issue 6, 2013
From the journal:

New Journal of Chemistry

Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions†

Xin Li,a   Hao-Yuan Wanga  and  Zhang-Jie Shi*ab  

* Corresponding authors

a Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, China
E-mail: zshi@pku.edu.cn
Fax: +86-10-6276-0890
Tel: +86-10-6276-0890

b State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

A mild and efficient method has been developed for the direct dehydrogenative alkylation of unprotonated pyridine derivatives. The avoidance of using acids and transition-metals makes this protocol “greener” and more practical for the synthesis of substituted pyridines.

Graphical abstract: Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions

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Article information

DOI
https://doi.org/10.1039/C3NJ00095H
Article type
Letter
Submitted
23 Jan 2013
Accepted
03 Apr 2013
First published
03 Apr 2013

New J. Chem., 2013,37, 1704-1706

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Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions

X. Li, H. Wang and Z. Shi, New J. Chem., 2013, 37, 1704 DOI: 10.1039/C3NJ00095H

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