Issue 42, 2013

Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(i) site that is resistant to O2 oxidation

Abstract

Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(II) coordination yields a square planar (N/O)4 coordination environment, while reduction yields an O2 inert linear bis-His Cu(I) centre.

Graphical abstract: Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(i) site that is resistant to O2 oxidation

Supplementary files

Article information

Article type
Communication
Submitted
15 1 2013
Accepted
15 4 2013
First published
23 4 2013

Chem. Commun., 2013,49, 4797-4799

Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation

K. L. Peck, H. S. Clewett, J. C. Schmitt and J. Shearer, Chem. Commun., 2013, 49, 4797 DOI: 10.1039/C3CC40326B

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