Issue 26, 2013

Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

Abstract

A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional 12C/1H and heavy stable isotope 13C/2H-labeled chelator–amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals.

Graphical abstract: Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

Supplementary files

Article information

Article type
Communication
Submitted
19 12 2012
Accepted
13 2 2013
First published
14 2 2013

Chem. Commun., 2013,49, 2697-2699

Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

D. Zeng and C. J. Anderson, Chem. Commun., 2013, 49, 2697 DOI: 10.1039/C3CC39071C

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