Issue 21, 2013

Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

Abstract

Metallopeptides containing both the complex Cu2+-glycyl-glycyl-histidine (Cu-GGH) and the sequence WRWYCR were shown to possess antimicrobial activity against a variety of pathogenic bacteria, as well as bind to and cleave a variety of nucleic acids, suggesting potential mechanisms for antimicrobial activity that involve binding and/or irreversible cleavage of bacterial nucleic acids.

Graphical abstract: Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

Supplementary files

Article information

Article type
Communication
Submitted
15 12 2012
Accepted
24 1 2013
First published
24 1 2013

Chem. Commun., 2013,49, 2118-2120

Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

J. C. Joyner, W. F. Hodnick, A. S. Cowan, D. Tamuly, R. Boyd and J. A. Cowan, Chem. Commun., 2013, 49, 2118 DOI: 10.1039/C3CC38977D

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