Issue 24, 2024

Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

Abstract

Immunotherapy is an important approach in cancer treatment. Transdermal administration is emerging as a promising method for delivering immunotherapeutics. Dissolving microneedles are made mainly of soluble or biodegradable polymers and have garnered widespread attention due to their painlessness, safety, convenience, excellent drug loading capacity, and easy availability of various materials, making them an ideal transdermal delivery system. This review comprehensively summarized the preparation methods, materials, and applications of dissolving microneedles in cancer vaccines, immune checkpoint inhibitors, and adoptive cell therapy. Additionally, the challenges and perspectives associated with their future clinical translation are discussed.

Graphical abstract: Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

Article information

Article type
Review Article
Submitted
29 3 2024
Accepted
22 5 2024
First published
10 6 2024

J. Mater. Chem. B, 2024,12, 5812-5822

Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

M. Xiang, C. Yang, L. Zhang, S. Wang, Y. Ren and M. Gou, J. Mater. Chem. B, 2024, 12, 5812 DOI: 10.1039/D4TB00659C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements