Issue 18, 2024

Recent advances in targeted drug delivery for the treatment of glioblastoma

Abstract

Glioblastoma multiforme (GBM) is one of the highly malignant brain tumors characterized by significant morbidity and mortality. Despite the recent advancements in the treatment of GBM, major challenges persist in achieving controlled drug delivery to tumors. The management of GBM poses considerable difficulties primarily due to unresolved issues in the blood–brain barrier (BBB)/blood–brain tumor barrier (BBTB) and GBM microenvironment. These factors limit the uptake of anti-cancer drugs by the tumor, thus limiting the therapeutic options. Current breakthroughs in nanotechnology provide new prospects concerning unconventional drug delivery approaches for GBM treatment. Specifically, swimming nanorobots show great potential in active targeted delivery, owing to their autonomous propulsion and improved navigation capacities across biological barriers, which further facilitate the development of GBM-targeted strategies. This review presents an overview of technological progress in different drug administration methods for GBM. Additionally, the limitations in clinical translation and future research prospects in this field are also discussed. This review aims to provide a comprehensive guideline for researchers and offer perspectives on further development of new drug delivery therapies to combat GBM.

Graphical abstract: Recent advances in targeted drug delivery for the treatment of glioblastoma

Article information

Article type
Review Article
Submitted
12 3 2024
Accepted
29 3 2024
First published
03 4 2024

Nanoscale, 2024,16, 8689-8707

Recent advances in targeted drug delivery for the treatment of glioblastoma

M. Mao, Y. Wu and Q. He, Nanoscale, 2024, 16, 8689 DOI: 10.1039/D4NR01056F

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