Issue 19, 2024

A metal–organic cage-derived cascade antioxidant nanozyme to mitigate renal ischemia-reperfusion injury

Abstract

In the field of contemporary medicine, inflammation has emerged as a significant concern in global public health. Among the current anti-inflammatory strategies, nanozymes possess distinctive advantages and demonstrate unexpected efficacy in combating inflammation. However, the indeterminate structures and limited enzyme-like activity exhibited by most developed nanozymes impede their clinical translation and therapeutic effectiveness. In this paper, we developed a nanozyme derived from a well-defined metal–organic cage (MOC). The oxidized MOC (MOC-O), containing pyridine nitrogen oxide moieties, exhibited effective cascade superoxide dismutase (SOD) and catalase (CAT)-like activities for scavenging reactive oxygen species (ROS). This ROS scavenging ability was confirmed through flow cytometry analysis using DCFH-DA in a hypoxia/reoxygenation (H/R) model, where MOC-O significantly alleviated oxidative stress. Furthermore, the administration of MOC-O resulted in preserved renal function during renal ischemia-reperfusion (I/R) injury due to downregulated oxidative stress levels and reduced cell apoptosis.

Graphical abstract: A metal–organic cage-derived cascade antioxidant nanozyme to mitigate renal ischemia-reperfusion injury

Supplementary files

Article information

Article type
Paper
Submitted
22 2 2024
Accepted
04 4 2024
First published
04 4 2024

Nanoscale, 2024,16, 9406-9411

A metal–organic cage-derived cascade antioxidant nanozyme to mitigate renal ischemia-reperfusion injury

C. Huang, Y. Deng, R. Ma, H. Ge, F. Gong, J. Yang, X. Zhu and Y. Wang, Nanoscale, 2024, 16, 9406 DOI: 10.1039/D4NR00742E

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