Issue 5, 2024

Development of polypeptide-based materials toward messenger RNA delivery

Abstract

Messenger RNA (mRNA)-based therapeutic agents have demonstrated significant potential in recent times, particularly in the context of the COVID-19 pandemic outbreak. As a promising prophylactic and therapeutic strategy, polypeptide-based mRNA delivery systems attract significant interest because of their low cost, simple preparation, tuneable sizes and morphology, convenient large-scale production, biocompatibility, and biodegradability. In this review, we begin with a brief discussion of the synthesis of polypeptides, followed by a review of commonly used polypeptides in mRNA delivery, including classical polypeptides and cell-penetrating peptides. Then, the challenges against mRNA delivery, including extracellular, intracellular, and clinical barriers, are discussed in detail. Finally, we highlight a range of strategies for polypeptide-based mRNA delivery, offering valuable insights into the advancement of polypeptide-based mRNA carrier development.

Graphical abstract: Development of polypeptide-based materials toward messenger RNA delivery

Article information

Article type
Minireview
Submitted
06 11 2023
Accepted
24 12 2023
First published
26 12 2023

Nanoscale, 2024,16, 2250-2264

Development of polypeptide-based materials toward messenger RNA delivery

B. Zhao, X. Zhang, M. S. Bickle, S. Fu, Q. Li and F. Zhang, Nanoscale, 2024, 16, 2250 DOI: 10.1039/D3NR05635J

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