Issue 6, 2024

Cooperative dissolution of peptidomimetic vesicles and amyloid β fibrils

Abstract

The aggregation of amyloid proteins in the brain is a significant neurotoxic event that contributes to neurodegenerative disorders. The aggregation of amyloid beta (Aβ), particularly Aβ42 monomers, into various forms such as oligomers, protofibrils, fibrils, and amyloid plaques is a key pathological feature in Alzheimer's disease. As a result, Aβ42 is a primary target and the development of molecular strategies for the dissolution of Aβ42 aggregates is considered a promising approach to mitigating Alzheimer's disease pathology. A set of pyrene-conjugated peptidomimetics derived from Aβ14-23 (AkdcPy, AkdmPy, and AkdnPy) by incorporating an unnatural amino acid [kd: cyclo(Lys-Asp)] were studied for their ability to modulate Aβ42 aggregation. AkdcPy and AkdmPy formed vesicular structures in aqueous media. The vesicles of AkdmPy loaded with the neuroprotective compound berberine (Ber), dissipated mutually in the presence of preformed Aβ42 fibrils. During this process, the active drug Ber was released. This work is expected to inspire the development of drug-loaded peptidomimetic-based therapeutic formulations to modulate disorders associated with amyloid toxicity.

Graphical abstract: Cooperative dissolution of peptidomimetic vesicles and amyloid β fibrils

Supplementary files

Article information

Article type
Paper
Submitted
25 9 2023
Accepted
04 1 2024
First published
16 1 2024

Nanoscale, 2024,16, 2993-3005

Cooperative dissolution of peptidomimetic vesicles and amyloid β fibrils

S. Dinda, D. Ghosh and T. Govindaraju, Nanoscale, 2024, 16, 2993 DOI: 10.1039/D3NR04847K

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