Issue 8, 2024

A monofunctional Pt(ii) complex combats triple negative breast cancer by triggering lysosome-dependent cell death

Abstract

Monofunctional Pt(II) complexes with potent efficacy to overcome the drawbacks of current platinum drugs represent a promising therapeutic approach for triple negative breast cancer (TNBC). A heterocyclic-ligated monofunctional Pt(II) complex PtL with a unique action of mode was designed and investigated. PtL induced DNA single-strand breaks and caused genomic instability in TNBC cells. Mechanism studies demonstrated that PtL disrupted lysosomal acidity and function, which in turn triggered lysosome-dependent cell death. Furthermore, PtL showed convincing suppression in the tube forming and cell migratory abilities against the metastatic potential of TNBC cells. The synthesis and investigation of PtL revealed its potential value as an anti-TNBC drug and extended the family of monofunctional Pt(II) complexes.

Graphical abstract: A monofunctional Pt(ii) complex combats triple negative breast cancer by triggering lysosome-dependent cell death

Supplementary files

Article information

Article type
Paper
Submitted
27 10 2023
Accepted
11 1 2024
First published
24 1 2024

Dalton Trans., 2024,53, 3808-3817

A monofunctional Pt(II) complex combats triple negative breast cancer by triggering lysosome-dependent cell death

X. Shen, Y. Peng, Z. Yang, R. Li, H. Zhou, X. Ye, Z. Han and X. Shi, Dalton Trans., 2024, 53, 3808 DOI: 10.1039/D3DT03598K

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