Issue 41, 2023

Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration

Abstract

Scaffolds are an essential component in bone tissue engineering (BTE). However, most of the current BTE scaffolds are homogeneous structures and do not resemble the graded architectures of native bone. In the current study, four types of biomimicking scaffold designs based on gyroid (G) and primitive (P) units with radially graded pore sizes were devised, and scaffolds of these designs with two porosity groups (65 vol% and 75 vol%) were fabricated via digital light processing (DLP) 3D printing using biphasic calcium phosphate (BCP). Scaffolds of the gyroid–gyroid (G–G) design displayed better dimensional accuracy, compressive property, and cell proliferation rate than gyroid–primitive (G–P), primitive–gyroid (P–G), and primitive–primitive (P–P) scaffolds. Subsequently, graded G–G scaffolds with different porosities were fabricated and the relationship between compressive strength and porosity was determined. Furthermore, the sintered BCP bioceramics fabricated via current manufacturing process exhibited excellent biocompatibility and bioactivity, indicating their high potential for BTE.

Graphical abstract: Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration

  • This article is part of the themed collection: #MyFirstJMCB

Article information

Article type
Paper
Submitted
13 7 2023
Accepted
27 9 2023
First published
11 10 2023

J. Mater. Chem. B, 2023,11, 9961-9974

Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration

Y. Wang, S. Chen, H. Liang, J. Bai and M. Wang, J. Mater. Chem. B, 2023, 11, 9961 DOI: 10.1039/D3TB01573D

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