Issue 31, 2023

Oxygen-releasing biomaterials for regenerative medicine

Abstract

Oxygen is critical to the survival, function and fate of mammalian cells. Oxygen tension controls cellular behavior through metabolic programming, which in turn controls tissue regeneration. A variety of biomaterials with oxygen-releasing capabilities have been developed to provide oxygen supply to ensure cell survival and differentiation for therapeutic efficacy, and to prevent hypoxia-induced tissue damage and cell death. However, controlling the oxygen release with spatial and temporal accuracy is still technically challenging. In this review, we provide a comprehensive overview of organic and inorganic materials available as oxygen sources, including hemoglobin-based oxygen carriers (HBOCs), perfluorocarbons (PFCs), photosynthetic organisms, solid and liquid peroxides, and some of the latest materials such as metal–organic frameworks (MOFs). Additionally, we introduce the corresponding carrier materials and the oxygen production methods and present state-of-the-art applications and breakthroughs of oxygen-releasing materials. Furthermore, we discuss the current challenges and the future perspectives in the field. After reviewing the recent progress and the future perspectives of oxygen-releasing materials, we predict that smart material systems that combine precise detection of oxygenation and adaptive control of oxygen delivery will be the future trend for oxygen-releasing materials in regenerative medicine.

Graphical abstract: Oxygen-releasing biomaterials for regenerative medicine

Article information

Article type
Review Article
Submitted
28 3 2023
Accepted
23 6 2023
First published
26 6 2023

J. Mater. Chem. B, 2023,11, 7300-7320

Oxygen-releasing biomaterials for regenerative medicine

Z. Wang, T. Chen, X. Li, B. Guo, P. Liu, Z. Zhu and R. X. Xu, J. Mater. Chem. B, 2023, 11, 7300 DOI: 10.1039/D3TB00670K

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