Issue 8, 2023

Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides

Abstract

A nickel-catalysed reductive cross-coupling reaction between 2-bromo cycloalkenyl carboxylic acids and alkyl bromides has been developed, affording all-carbon tetrasubstituted cycloalkenes in moderate to excellent yields up to 92%. Mechanistic studies indicated that the carboxylic acid group plays an important assisting role in this sterically demanding coupling reaction.

Graphical abstract: Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides

Supplementary files

Article information

Article type
Research Article
Submitted
02 2 2023
Accepted
09 3 2023
First published
10 3 2023

Org. Chem. Front., 2023,10, 1897-1902

Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides

J. An, X. Zhou, Y. Zhang, Z. Ye, Q. Guo, H. Song, Z. Song, X. Liu and Y. Qin, Org. Chem. Front., 2023, 10, 1897 DOI: 10.1039/D3QO00155E

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