Issue 6, 2023

Photocatalytic dehydrations for the Ritter reaction

Abstract

The Ritter reaction is a powerful method for the synthesis of amides; however, the photoinduced Ritter reaction of alcohols is rarely reported. We herein report a simple and additive-free photocatalytic dehydration method for the efficient direct conversion of benzyl alcohols to the corresponding amides using an organic photocatalyst 2,4,6-triphenylpyrylium salt. Experimental and computational mechanistic analyses show that a non-conventional generation process of a carbocation is involved in this photoinduced Ritter reaction.

Graphical abstract: Photocatalytic dehydrations for the Ritter reaction

Supplementary files

Article information

Article type
Research Article
Submitted
28 12 2022
Accepted
09 2 2023
First published
11 2 2023

Org. Chem. Front., 2023,10, 1375-1379

Photocatalytic dehydrations for the Ritter reaction

L. Bao, B. Zhang, Z. Wang and X. Chen, Org. Chem. Front., 2023, 10, 1375 DOI: 10.1039/D2QO02046G

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