Visible-light-promoted C(sp3)–H thiolation of aliphatic ethers with thiosulfonates

Wen-Zhu Bi; Qing-Pu Liu; Chen-Yu Li; Wen-Jie Zhang; Su-Xiang Feng; Yang Geng; Xiao-Lan Chen; Ling-Bo Qu

doi:10.1039/D3NJ01029E

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Visible-light-promoted C(sp³)–H thiolation of aliphatic ethers with thiosulfonates†

Wen-Zhu Bi,

*^ab Qing-Pu Liu,^a Chen-Yu Li,^a Wen-Jie Zhang,^a Su-Xiang Feng,*^bcd Yang Geng,*^e Xiao-Lan Chen

^f and Ling-Bo Qu^f

Author affiliations

* Corresponding authors

^a School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China

^b Henan Engineering Research Center of Modern Chinese Medicine Research, Development and Application, Zhengzhou, China

^c Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China
E-mail: fengsx221@163.com

^d Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan province & Education Ministry of P. R. China, Zhengzhou, China

^e Department of Pharmacy, Zhengzhou Railway Vocational and Technical College, Zhengzhou, China
E-mail: gengyang0001@163.com

^f College of Chemistry, Zhengzhou University, Zhengzhou, China

Abstract

A visible-light-promoted direct thiolation of α-C(sp³)–H in ethers with thiosulfonates was developed for the preparation of α-arylthioethers using easily availably Na₂-eosin Y and TBHP as a photocatalyst and oxidant. This reaction occurred smoothly under the irradiation of 5 W blue light at room temperature and generated the corresponding products in good to excellent yields.

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Article information

DOI: https://doi.org/10.1039/D3NJ01029E
Article type: Communication
Submitted: 03 3 2023
Accepted: 24 4 2023
First published: 24 4 2023

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New J. Chem., 2023,47, 9035-9039

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Visible-light-promoted C(sp³)–H thiolation of aliphatic ethers with thiosulfonates

W. Bi, Q. Liu, C. Li, W. Zhang, S. Feng, Y. Geng, X. Chen and L. Qu, New J. Chem., 2023, 47, 9035 DOI: 10.1039/D3NJ01029E

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