Issue 7, 2023

Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

Abstract

The field of nanozymes is developing rapidly. In particular, glutathione peroxidase (GPx)-like nanozymes, which catalytically reduce H2O2/organic hydroperoxides to H2O/alcohols, have attracted considerable attention. GPx-like nanozymes are powerful antioxidant enzymes known to combat oxidative stress. They have broad applications, including cytoprotection, anti-inflammation, neuroprotection, tumor therapy, and anti-aging. Although much progress has been made, GPx-like nanozymes have not been well discussed or fully reviewed as other nanozymes. This review aims to summarize recent advances on GPx-like nanozymes from the vantage point of mechanism, classification, and bioapplication. Future prospects for advancing their design and application are also discussed.

Graphical abstract: Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

Supplementary files

Article information

Article type
Review Article
Submitted
22 11 2022
Accepted
28 1 2023
First published
30 1 2023

Biomater. Sci., 2023,11, 2292-2316

Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication

Y. Lai, J. Wang, N. Yue, Q. Zhang, J. Wu, W. Qi and R. Su, Biomater. Sci., 2023, 11, 2292 DOI: 10.1039/D2BM01915A

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